Abstract
A new mouse model reported in this issue of Cancer Cell implies that VEGF/KDR-mediated paracrine effects induced by the lytic cycle vGPCR signaling protein encoded by human Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) may be involved in promoting the proliferation of the KSHV latently infected spindle endothelial cells of Kaposi's sarcoma.
MeSH terms
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Animals
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Cell Transformation, Neoplastic*
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Herpesvirus 8, Human / pathogenicity
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Herpesvirus 8, Human / physiology*
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Humans
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Mice
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Models, Animal
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Neovascularization, Pathologic
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Receptors, Chemokine / metabolism*
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Sarcoma, Kaposi / pathology*
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Sarcoma, Kaposi / virology*
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Viral Proteins / metabolism*
Substances
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ORF74 protein, Human herpesvirus 8
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Receptors, Chemokine
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Viral Proteins