Initiation of angiogenic Kaposi's sarcoma lesions

Cancer Cell. 2003 Jan;3(1):1-3. doi: 10.1016/s1535-6108(03)00002-3.

Abstract

A new mouse model reported in this issue of Cancer Cell implies that VEGF/KDR-mediated paracrine effects induced by the lytic cycle vGPCR signaling protein encoded by human Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) may be involved in promoting the proliferation of the KSHV latently infected spindle endothelial cells of Kaposi's sarcoma.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic*
  • Herpesvirus 8, Human / pathogenicity
  • Herpesvirus 8, Human / physiology*
  • Humans
  • Mice
  • Models, Animal
  • Neovascularization, Pathologic
  • Receptors, Chemokine / metabolism*
  • Sarcoma, Kaposi / pathology*
  • Sarcoma, Kaposi / virology*
  • Viral Proteins / metabolism*

Substances

  • ORF74 protein, Human herpesvirus 8
  • Receptors, Chemokine
  • Viral Proteins