In this paper we synthesised two kinds of hydrophilic liquid crystal, i.e. cholesteryl triethenyl glycol carbonate (TCC), cholesteryl tetraethenyl glycol carbonate (TeCC), which were blended with PLA with certain contents to form composite membranes. Contact angle test showed that the contact angle decreases with the increase of liquid crystal. The blood-compatibility of the composite membranes was assessed by blood clotting time and hemolysis ratio which showed that these PLA/liquid crystal composite membranes with the content of 30%-40% liquid crystal appeared to be beneficial in improving the blood compatibility and anticoagulation.