Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid

Phytother Res. 2003 Jan;17(1):86-8. doi: 10.1002/ptr.1082.

Abstract

In a model of the high blood viscosity syndrome, developed after myocardial infarction in rats, it was observed that a therapy of a combination of diquertin (20 mg/kg) and ascorbic acid (50 mg/kg) for a -period of 6 days, resulted in an improvement of haemorheological indices. The decrease in blood -viscosity was primarily due to an improved deformability of erythrocytes, and to some extent, due to a decrease in the content of plasma fibrinogen and erythrocyte aggregation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / pharmacology
  • Ascorbic Acid / therapeutic use*
  • Blood Viscosity / drug effects
  • Disease Models, Animal
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Erythrocyte Aggregation / drug effects
  • Fibrinogen / drug effects
  • Male
  • Myocardial Infarction / drug therapy*
  • Phytotherapy*
  • Quercetin / administration & dosage
  • Quercetin / analogs & derivatives
  • Quercetin / pharmacology
  • Quercetin / therapeutic use*
  • Rats
  • Rats, Wistar

Substances

  • Antioxidants
  • diquertin
  • Fibrinogen
  • Quercetin
  • Ascorbic Acid