Abstract
In a model of the high blood viscosity syndrome, developed after myocardial infarction in rats, it was observed that a therapy of a combination of diquertin (20 mg/kg) and ascorbic acid (50 mg/kg) for a -period of 6 days, resulted in an improvement of haemorheological indices. The decrease in blood -viscosity was primarily due to an improved deformability of erythrocytes, and to some extent, due to a decrease in the content of plasma fibrinogen and erythrocyte aggregation.
Copyright 2003 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / administration & dosage
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Antioxidants / pharmacology
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Antioxidants / therapeutic use*
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Ascorbic Acid / administration & dosage
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Ascorbic Acid / pharmacology
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Ascorbic Acid / therapeutic use*
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Blood Viscosity / drug effects
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Disease Models, Animal
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Drug Administration Schedule
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Drug Therapy, Combination
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Erythrocyte Aggregation / drug effects
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Fibrinogen / drug effects
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Male
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Myocardial Infarction / drug therapy*
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Phytotherapy*
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Quercetin / administration & dosage
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Quercetin / analogs & derivatives
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Quercetin / pharmacology
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Quercetin / therapeutic use*
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Rats
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Rats, Wistar
Substances
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Antioxidants
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diquertin
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Fibrinogen
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Quercetin
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Ascorbic Acid