Targeted retroviral infection of tumor cells by receptor cooperation

J Virol. 2003 Feb;77(4):2753-6. doi: 10.1128/jvi.77.4.2753-2756.2003.

Abstract

Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neoplasm / metabolism*
  • Carcinoembryonic Antigen / metabolism
  • Genetic Vectors
  • Humans
  • Immunoglobulin Fragments / metabolism*
  • Membrane Glycoproteins / metabolism
  • Moloney murine leukemia virus / metabolism
  • Moloney murine leukemia virus / pathogenicity*
  • Receptors, Virus / metabolism*
  • Tumor Cells, Cultured

Substances

  • Antibodies, Neoplasm
  • Carcinoembryonic Antigen
  • Immunoglobulin Fragments
  • Membrane Glycoproteins
  • Receptors, Virus
  • ecotropic murine leukemia virus receptor