Abstract
Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Neoplasm / metabolism*
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Carcinoembryonic Antigen / metabolism
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Genetic Vectors
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Humans
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Immunoglobulin Fragments / metabolism*
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Membrane Glycoproteins / metabolism
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Moloney murine leukemia virus / metabolism
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Moloney murine leukemia virus / pathogenicity*
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Receptors, Virus / metabolism*
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Tumor Cells, Cultured
Substances
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Antibodies, Neoplasm
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Carcinoembryonic Antigen
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Immunoglobulin Fragments
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Membrane Glycoproteins
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Receptors, Virus
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ecotropic murine leukemia virus receptor