Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients

AIDS. 2003 Jan 24;17(2):257-60. doi: 10.1097/00002030-200301240-00017.

Abstract

We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mononuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cytotoxicity, Immunologic
  • Disease Progression
  • HIV Infections / immunology*
  • HIV Long-Term Survivors*
  • HIV-1*
  • Humans
  • Killer Cells, Natural / immunology
  • Receptors, Immunologic / blood*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Tumor Cells, Cultured

Substances

  • Receptors, Immunologic