New technologies for the identification of markers for early detection of ovarian cancer

Curr Opin Obstet Gynecol. 2003 Feb;15(1):51-5. doi: 10.1097/00001703-200302000-00008.

Abstract

Purpose of review: The ovarian cancer screening regimens in current use fail to identify disease at an early curable stage.

Recent findings: New technologies are emerging that facilitate the identification of diagnostic tumor markers. In particular, high throughput techniques using microarray technology and proteomic screening have enriched the study of protein expression by ovarian cancer cells.

Summary: Further evaluation of serum proteins associated with ovarian cancer holds promise for the development of a tumor marker panel that could aid in the early diagnosis of ovarian cancer, and save lives.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • CA-125 Antigen / analysis*
  • DNA, Neoplasm / analysis
  • Electrophoresis, Gel, Two-Dimensional / methods*
  • Female
  • Humans
  • Mass Screening / methods*
  • Oligonucleotide Array Sequence Analysis*
  • Ovarian Neoplasms / blood
  • Ovarian Neoplasms / diagnosis*
  • Prognosis
  • RNA, Neoplasm / analysis
  • Sensitivity and Specificity
  • Time Factors

Substances

  • Biomarkers, Tumor
  • CA-125 Antigen
  • DNA, Neoplasm
  • RNA, Neoplasm