The changing rule of leachate quality in Xiaping Sanitary Landfill was studied using pilot-scale leaching test for waste pollutants. And the parameters for Pollutants Leaching Model were determined using the data from the test by exponential regression method. Both the results from the test and the monitoring data in site indicated that the leachate concentration reached its maximum with COD of 31,581 mg/L after 75 days. Meanwhile, the accuracy of this prediction model was testified by comparing with the monitoring data in site, that means the model and its parameters achieved by leaching test for pollutants load can be used to predict the leachate quality variation in MSW landfills. Thus it provides a scientific numerical model and leaching test method for leachate quality prediction and basis for designing and managing leachate treatment facilities.