Ubiquitin-dependent proteolysis in neurons

News Physiol Sci. 2003 Feb:18:29-33. doi: 10.1152/nips.01408.2002.

Abstract

Various studies identified the ubiquitin-proteasome system as the prime suspect in causing neurodegenerative diseases. The present review summarizes our current knowledge about the expression, regulation, and functions of this major protein degradation pathway in the brain, with particular reference to the pathogenesis of associated neurological diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Diseases / metabolism*
  • Brain Diseases / pathology
  • Cysteine Endopeptidases / metabolism*
  • Humans
  • Multienzyme Complexes / metabolism*
  • Neurons / metabolism*
  • Neurons / pathology
  • Proteasome Endopeptidase Complex
  • Ubiquitin / metabolism*

Substances

  • Multienzyme Complexes
  • Ubiquitin
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex