Objective: To understand with greater clearness the effect of overexpression of cyclins gene and the potential implications of it for tumorgenesis in breast.
Methods: We assayed the expression of cyclins D1, E and A in different types of human breast diseases by immunohistochemical staining.
Results: Significant difference was seen among the malignant tumor, benign tumor and dysplasis(P < 0.001). The expressive intensity of above three kind of cyclins in malignant tumor was the highest, that in benign tumor was higher, and that in dysplasis was low.
Conclusion: These data suggest that the expressive intensity of cyclins gene may serve as an indicator for malignant intensity of tumors. The expressive ratio difference of cyclins E and A between infiltrating ductal carcinoma and infiltrating lobular carcinoma may imply that there are different mechanisms involving the occurrence of different histological types of breast tumor.