Abstract
T cell mediated immunity and in particular CD8+ T cells are pivotal for the control of most viral infections. T cells exclusively exert their antiviral effect through close cellular interaction with relevant virus-infected target cells in vivo. It is therefore imperative that efficient mechanisms exist, which will rapidly direct newly generated effector T cells to sites of viral replication. In the present report we have reviewed our present knowledge concerning the molecular interactions, which are important in targeting of effector CD8+ T cells to sites of viral infection.
MeSH terms
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Animals
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / virology*
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Cell Adhesion Molecules / genetics
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Cell Adhesion Molecules / immunology*
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Cell Movement / immunology*
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Chemokines / chemistry
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Chemokines / classification
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Chemokines / immunology*
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Humans
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Integrins / genetics
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Integrins / immunology
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Receptors, Chemokine / metabolism
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Selectins / genetics
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Selectins / immunology
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / virology*
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Virus Diseases / immunology
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Viruses / immunology
Substances
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Cell Adhesion Molecules
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Chemokines
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Integrins
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Receptors, Chemokine
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Selectins