Recognition of a novel stage of betaherpesvirus latency in human herpesvirus 6

J Virol. 2003 Feb;77(3):2258-64. doi: 10.1128/jvi.77.3.2258-2264.2003.

Abstract

Latency-associated transcripts of human herpesvirus 6 (H6LTs) (K. Kondo et al. J. Virol. 76:4145-4151, 2002) were maximally expressed at a fairly stable intermediate stage between latency and reactivation both in vivo and in vitro. H6LTs functioned as sources of immediate-early protein 1 at this stage, which up-regulated the viral reactivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Hematopoietic Stem Cell Transplantation
  • Herpesvirus 6, Human / genetics
  • Herpesvirus 6, Human / physiology*
  • Humans
  • Immediate-Early Proteins / genetics
  • Infant
  • Open Reading Frames
  • Phosphoproteins / genetics
  • RNA, Messenger / analysis
  • RNA, Viral / analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tetradecanoylphorbol Acetate / pharmacology
  • Virus Latency*

Substances

  • Immediate-Early Proteins
  • Phosphoproteins
  • RNA, Messenger
  • RNA, Viral
  • immediate-early 1 protein, human herpesvirus 6
  • Tetradecanoylphorbol Acetate