[Effect and mechanism of active fraction A guizhi decoction on dual-directional thermoregulation: effect on heat shock protein in hypothalamus of rats]

Zhongguo Zhong Yao Za Zhi. 2000 Oct;25(10):619-21.
[Article in Chinese]

Abstract

Objective: To investigate the effect of active fraction A in Guizhi Decoction (Fr.A) on dual-directional thermoregulation and its mechanism of influencing heat shock protein (HSP) in hypothalamus.

Method: Using Western blot method to measure HSP of hypothalamus in febrile and hypothermal rats.

Results: Regulating the body temperature in dual-direction, Fr.A could antagonize the decrease of HSP contents of hypothalamus in hypothermal rats induced by aminopyrine, and abate the HSP content in febrile rats induced by yeast.

Conclusion: Fr.A adjusts the body temperature through regulating the contents of HSP of hypothalamus in febrile and hypothermal rats.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Temperature Regulation / drug effects*
  • Drug Combinations
  • Drugs, Chinese Herbal / pharmacology*
  • Fever / chemically induced
  • Fever / metabolism*
  • Heat-Shock Proteins / metabolism*
  • Hypothalamus / metabolism
  • Hypothermia / chemically induced
  • Hypothermia / metabolism*
  • Male
  • Random Allocation
  • Rats
  • Rats, Wistar

Substances

  • Drug Combinations
  • Drugs, Chinese Herbal
  • Heat-Shock Proteins