Nitric oxide in liver transplantation: pathobiology and clinical implications

Vijay Shah; Patrick S Kamath

doi:10.1053/jlts.2003.36244

Nitric oxide in liver transplantation: pathobiology and clinical implications

Liver Transpl. 2003 Jan;9(1):1-11. doi: 10.1053/jlts.2003.36244.

Authors

Vijay Shah¹, Patrick S Kamath

Affiliation

¹ GI Research Unit and Advanced Liver Disease Study Group, Department of Medicine, Alfred 2-435, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. shah.vijay@mayo.edu.

PMID: 12514766
DOI: 10.1053/jlts.2003.36244

Abstract

The gaseous molecule nitric oxide is involved in a variety of liver transplant-relevant processes, including ischemia-reperfusion injury, acute cellular rejection, and circulatory changes characteristic of advanced liver disease. This review article focuses on new advances relating to the role of nitric oxide in these syndromes with an emphasis on pathobiology and potential clinical implications.

Publication types

Review

MeSH terms

Graft Rejection / physiopathology
Hepatopulmonary Syndrome / physiopathology
Humans
Liver Transplantation / physiology*
Nitric Oxide / physiology*
Nitric Oxide Synthase / physiology
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Reperfusion Injury / physiopathology

Substances

Nitric Oxide
NOS1 protein, human
NOS2 protein, human
NOS3 protein, human
Nitric Oxide Synthase
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III