[Which species actually exist in relation with time and pH when compounds exhibit several dissociation and kinetic constants: the striking case of a thieno-1,4-diazepine]

B Legouin; J L Burgot

[Which species actually exist in relation with time and pH when compounds exhibit several dissociation and kinetic constants: the striking case of a thieno-1,4-diazepine]

Ann Pharm Fr. 2002 Nov;60(6):398-402.

[Article in French]

Authors

B Legouin¹, J L Burgot

Affiliation

¹ Laboratoire de Chimie Analytique et Bromatologie, UPRES 2231, UFR des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, 2, avenue du Pr Léon-Bernard, CS 34317, F 35043 Rennes Cedex, France.

PMID: 12514506

Abstract

A solution of a molecule having several dissociation and kinetic constants evolves with time and pH-value. Now it is important from a pharmacological standpoint to know which species actually exist in solution. The knowledge of the kinetic and dissociation constants allows to plot the concentrations profiles versus time and versus pH-values of the whole protolytes. This is illustrated with a thieno-1,4-diazepine.

Publication types

English Abstract

MeSH terms

Algorithms
Azepines / chemistry*
Dihydropyridines / chemistry*
Kinetics
Solutions

Substances

Azepines
Dihydropyridines
Solutions
thieno-1,4-diazepine