Natural killer cell activation receptors in innate immunity to infection

Wayne M Yokoyama; Anthony A Scalzo

doi:10.1016/s1286-4579(02)00034-5

Natural killer cell activation receptors in innate immunity to infection

Microbes Infect. 2002 Dec;4(15):1513-21. doi: 10.1016/s1286-4579(02)00034-5.

Authors

Wayne M Yokoyama¹, Anthony A Scalzo

Affiliation

¹ Howard Hughes Medical Institute, and Division of Rheumatology, Department of Medicine, Barnes-Jewish Hospital and Washington University School of Medicine, Box 8045, 660 South Euclid Avenue, Saint Louis, MO 63110, USA. yokoyama@imgate.wustl.edu

PMID: 12505523
DOI: 10.1016/s1286-4579(02)00034-5

Abstract

Natural killer (NK) cells are best known for their capacity to kill tumors but they are also critical in early innate responses to infection, especially herpesviruses. Recent studies indicate that NK cell receptors involved in tumor target specificity are also involved in responses to viral infections.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Immunity, Innate / immunology*
Killer Cells, Natural / immunology*
Killer Cells, Natural / metabolism*
Lymphocyte Activation*
Receptors, Immunologic / metabolism*
Virus Diseases / immunology*

Substances

Receptors, Immunologic