Pharmacology of Na+/Ca2+ exchanger

Ann N Y Acad Sci. 2002 Nov:976:513-9. doi: 10.1111/j.1749-6632.2002.tb04785.x.

Abstract

KB-R7943 inhibits the Na(+)/Ca(2+) exchanger in an independent manner or in a manner dependent on the direction of the current. This effect may be due to the experimental protocols bawed on the competition between the drug and external substrate ions. Some antiarrhythmic drugs inhibit NCX. A new column of NCX was added in Sicilian Gambit.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / pharmacology
  • Calcium / physiology
  • Models, Biological
  • Models, Cardiovascular
  • Sodium-Calcium Exchanger / antagonists & inhibitors*
  • Sodium-Calcium Exchanger / physiology*
  • Structure-Activity Relationship
  • Thiourea / analogs & derivatives*
  • Thiourea / pharmacology*

Substances

  • 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate
  • Anti-Arrhythmia Agents
  • Sodium-Calcium Exchanger
  • Thiourea
  • Calcium