Abstract
The ethyl acetate soluble extract of the dried roots of Ferula penninervis gave 17 new sesquiterpenes [15 of the guaiane-type, ferupennins A-O (1-15), and two of the eudesmane-type, 1alpha-hydroxy-2-oxo-5alpha,7beta,11betaH-eudesm-3-en-6alpha,12-olide (16) and penninervin (17)] and nine known sesquiterpenes. The structures of the new compounds were elucidated on the basis of spectroscopic evidence and X-ray analysis. The absolute configuration of ferupennin A (1) was determined by a modified Mosher method.
MeSH terms
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Acetates
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Acetylation
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Adult
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Crystallography, X-Ray
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Enzyme-Linked Immunosorbent Assay
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Ferula / chemistry*
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Humans
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Interleukin-1 / blood
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Interleukin-2 / blood
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Interleukin-4 / blood
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Lipopolysaccharides / pharmacology
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Spectrophotometry, Ultraviolet
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Tumor Necrosis Factor-alpha / metabolism
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Uzbekistan
Substances
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Acetates
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Interleukin-1
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Interleukin-2
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Lipopolysaccharides
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Sesquiterpenes
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Tumor Necrosis Factor-alpha
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Interleukin-4
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ethyl acetate