New cadinene sesquiterpenoids from the Formosan soft coral Xenia puerto-galerae

J Nat Prod. 2002 Dec;65(12):1853-6. doi: 10.1021/np0203281.

Abstract

Six new cadinene sesquiterpenoids, xenitorins A-F (1-6), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia puerto-galerae. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Colonic Neoplasms
  • Drug Screening Assays, Antitumor
  • Humans
  • Leukemia P388
  • Lung Neoplasms
  • Methylene Chloride
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Taiwan
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Sesquiterpenes
  • Methylene Chloride