New scalarane class sesterterpenes from an Indonesian sponge, Phyllospongia sp

J Nat Prod. 2002 Dec;65(12):1838-42. doi: 10.1021/np020311i.

Abstract

A series of scalarane class sesterterpenes (1-8) have been isolated from an Indonesian sponge, Phyllospongia sp. Their structures were determined by spectroscopic analysis and confirmed by single-crystal X-ray diffraction on compound 1. The absolute stereochemistry of 1 was established by modified Mosher's method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Screening Assays, Antitumor
  • Humans
  • Indonesia
  • KB Cells / drug effects
  • Methylation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Sesterterpenes
  • Spectroscopy, Fourier Transform Infrared
  • Stereoisomerism
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology
  • Tumor Cells, Cultured / drug effects
  • X-Ray Diffraction

Substances

  • Sesterterpenes
  • Terpenes