Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei

J Nat Prod. 2002 Dec;65(12):1820-3. doi: 10.1021/np0200865.

Abstract

Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their structures elucidated by spectroscopic data and X-ray diffraction analysis. The bitungolides are a new class of Theonella metabolites that inhibit dual-specificity phosphatase VHR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Indonesia
  • Microtubules / drug effects
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Phosphoric Monoester Hydrolases / antagonists & inhibitors*
  • Porifera / chemistry*
  • Pyrones / chemistry
  • Pyrones / isolation & purification*
  • Pyrones / pharmacology
  • Spectroscopy, Fourier Transform Infrared
  • X-Ray Diffraction

Substances

  • Enzyme Inhibitors
  • Pyrones
  • pironetin
  • Phosphoric Monoester Hydrolases