Abstract
Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids
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Animals
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Antineoplastic Agents
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Bromobenzenes / chemistry
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Bromobenzenes / isolation & purification*
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Bromobenzenes / pharmacology
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Drug Screening Assays, Antitumor
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Female
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Fiji
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Humans
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Leukemia
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Molecular Structure
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Ovarian Neoplasms
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Porifera
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Tumor Cells, Cultured / drug effects
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Tyrosine / analogs & derivatives
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Tyrosine / chemistry
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Tyrosine / isolation & purification*
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Tyrosine / pharmacology
Substances
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Alkaloids
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Antineoplastic Agents
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Bromobenzenes
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purealidin S
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purpuramine J
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Tyrosine