Purealidin S and purpuramine J, bromotyrosine alkaloids from the Fijian marine sponge Druinella sp

J Nat Prod. 2002 Dec;65(12):1798-801. doi: 10.1021/np020275n.

Abstract

Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids
  • Animals
  • Antineoplastic Agents
  • Bromobenzenes / chemistry
  • Bromobenzenes / isolation & purification*
  • Bromobenzenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Female
  • Fiji
  • Humans
  • Leukemia
  • Molecular Structure
  • Ovarian Neoplasms
  • Porifera
  • Tumor Cells, Cultured / drug effects
  • Tyrosine / analogs & derivatives
  • Tyrosine / chemistry
  • Tyrosine / isolation & purification*
  • Tyrosine / pharmacology

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Bromobenzenes
  • purealidin S
  • purpuramine J
  • Tyrosine