Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!

Cytometry B Clin Cytom. 2003 Jan;51(1):41-4. doi: 10.1002/cyto.b.10005.

Abstract

We report a case of a patient with two B-cell lymphoproliferative disorders: CD5(-)/CD23(+) B-cell chronic lymphocytic leukemia and CD5(+)/CD23(-) mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based molecular studies. The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • CD5 Antigens / analysis
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 13
  • Chromosomes, Human, Pair 14
  • Flow Cytometry
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
  • Lymph Nodes / pathology
  • Lymphoma, Mantle-Cell / complications
  • Lymphoma, Mantle-Cell / genetics*
  • Lymphoma, Mantle-Cell / pathology*
  • Male
  • Receptors, IgE / analysis
  • Translocation, Genetic*

Substances

  • CD5 Antigens
  • Receptors, IgE