Taxumairols X--Z, new taxoids from Taiwanese Taxus mairei

Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1561-5. doi: 10.1248/cpb.50.1561.

Abstract

In addition to 19-dydroxybaccatin III, 1beta-hydroxy-5 alpha-deacetylbaccatin I, taxayuntin G and 13-O-deacetyltaxumairol Z (4), three new taxane diterpenoids, taxumairols X (1), Y (2), Z (3) have been isolated from extracts of the Formosan Taxus mairei (LEMEE & LEVL.) S. Y. HU. Compounds 1-2 belong to the 11(15-->1)-abeo-taxane system, having a tetrahydrofuran ring at C-2, C-3, C-4 and C-20. The new compound 3 and 4, which was misidentified previously are derivatives of 11(15-->1)-abeo-taxane with an intact oxirane system. The structures of compounds 1-4 were elucidated on the basis of extensive two dimensional (2D)-NMR analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Paclitaxel / analogs & derivatives
  • Paclitaxel / isolation & purification*
  • Plant Components, Aerial / chemistry
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry
  • Taiwan
  • Taxoids*
  • Taxus / chemistry*

Substances

  • Taxoids
  • taxumairol-X
  • taxumairol-Y
  • taxumairol-Z
  • Paclitaxel