Abstract
The influence of gamma-GluHA and glutarylhistamine on the lipid peroxidation, cholesterol, phospholipid and liver aminotransferase activity was investigated using carbon tetrachloride-induced model of subacute liver damage. Pretreatment of rats with gamma-GluHA and glutarylhistamine prevented liver necrosis and normalized activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood plasma, lipid peroxidation in the liver and plasma, lipid profiles and cholesterol content in the liver and plasma.
MeSH terms
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Animals
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Carbon Tetrachloride Poisoning / drug therapy*
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Carbon Tetrachloride Poisoning / metabolism
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Chemical and Drug Induced Liver Injury / drug therapy*
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Chemical and Drug Induced Liver Injury / metabolism
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Disease Models, Animal
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Female
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Histamine / analogs & derivatives*
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Histamine / therapeutic use*
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Lipid Peroxidation / drug effects
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Liver / drug effects*
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Liver / metabolism
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Liver Function Tests
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Protective Agents / therapeutic use*
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Rats
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Silymarin / therapeutic use
Substances
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N-glutarylhistamine
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Protective Agents
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Silymarin
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gamma-glutamylhistamine
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Histamine