Antibacterial activity of a stearic acid derivative from Stemodia foliosa

Planta Med. 2002 Dec;68(12):1137-9. doi: 10.1055/s-2002-36346.

Abstract

From the hexane-soluble fraction of an ethanol extract from leaves and stems of Stemodia foliosa (Scrophulariaceae), the new stearic acid 4-[(n-pentoxy)phenethyl] ester (1) was isolated. This compound exhibited antibacterial properties at 10 microg/mL concentration by using disc diffusion method against Gram-positive bacteria Bacillus cereus and Bacillus subtilis and fast-acid bacterium Mycobacterium fortuitum. The structure of the new compound was elucidated by spectroscopic methods and by chemical conversion.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects*
  • Clarithromycin / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Scrophulariaceae*
  • Stearates / chemistry
  • Stearates / isolation & purification
  • Stearates / pharmacology*
  • Stearic Acids / chemistry
  • Stearic Acids / pharmacology

Substances

  • Anti-Bacterial Agents
  • Plant Extracts
  • Stearates
  • Stearic Acids
  • stearic acid 4-((n-pentoxy)phenethyl) ester
  • stearic acid
  • Clarithromycin