Artoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius

Fitoterapia. 2002 Dec;73(7-8):668-73. doi: 10.1016/s0367-326x(02)00226-5.

Abstract

A new prenylated flavone, named artoindonesianin P (1), was isolated from the tree bark of Artocarpus lanceifolius, together with three known related compounds, artobiloxanthone (2), cycloartobiloxanthone (3) and artonol B (4). The structure of artoindonesianin P 1 was determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1-4 exhibited significant cytotoxicity against murine P388 leukemia cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Artocarpus / chemistry*
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Molecular Structure
  • Plant Bark / chemistry
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Flavonoids
  • artoindonesianin P