Syntheses of novel substituted-boranophosphate nucleosides

Kamesh Vyakaranam; Geeta Rana; Bernard F Spielvogel; John A Maguire; Narayan S Hosmane

doi:10.1081/NCN-120015070

Syntheses of novel substituted-boranophosphate nucleosides

Nucleosides Nucleotides Nucleic Acids. 2002;21(8-9):581-98. doi: 10.1081/NCN-120015070.

Authors

Kamesh Vyakaranam¹, Geeta Rana, Bernard F Spielvogel, John A Maguire, Narayan S Hosmane

Affiliation

¹ Department of Chemistry and Biochemistry, Michael Faraday Laboratories, Northern Illinois University, DeKalb, IL 60115, USA.

PMID: 12484452
DOI: 10.1081/NCN-120015070

Abstract

A number of substituted (borano) nucleic acids, 3'-[diethylphosphite(cyano, carboxy, or carbamoyl) borano] deoxynucleosides (3a-4c) and 5'-[diethylphosphite(cyano or carboxy) borano] deoxynucleosides (6a-7d) were prepared by a variety of synthetic procedures. The syntheses of the pyrophosphates (2a-2c), as precursors for 3a-4c, are also described.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Boron Compounds / chemical synthesis*
Deoxyadenosines / chemical synthesis
Deoxycytidine / chemical synthesis
Molecular Structure
Nucleosides / chemical synthesis*
Organophosphorus Compounds / chemical synthesis*

Substances

Boron Compounds
Deoxyadenosines
Nucleosides
Organophosphorus Compounds
Deoxycytidine