Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design

Chem Rev. 2002 Dec;102(12):4459-88. doi: 10.1021/cr0101656.

Authors

Fabien Lecaille¹, Jadwiga Kaleta, Dieter Brömme

Affiliation

¹ Mount Sinai School of Medicine, Department of Human Genetics, Fifth Avenue at 100th Street, New York, New York 10029, USA.

PMID: 12475197
DOI: 10.1021/cr0101656

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cysteine Endopeptidases* / genetics
Cysteine Endopeptidases* / physiology
Cysteine Proteinase Inhibitors / chemical synthesis
Cysteine Proteinase Inhibitors / pharmacology
Disease / etiology
Drug Design
Humans
Mammals
Papain
Parasites / enzymology*
Parasitic Diseases / parasitology
Structure-Activity Relationship

Substances

Cysteine Proteinase Inhibitors
Cysteine Endopeptidases
Papain

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