[Preparation, analysis and anti-anemic action of peroral powders with ferrous oxalate. Ferosol. 2]

Medicina (Kaunas). 2002;38(1):69-76.
[Article in Lithuanian]

Abstract

Experiments with piglets showed good assimilation and metabolism of iron (II) in antianaemic powder Ferosol-1. In order to improve this drug, manganese, calcium (Ferosol-2, 1 composition) and ascorbic acid (Ferosol-2, 2 composition) were added. Manganese and ascorbic acid stimulate erythropoiesis and being strong reductants stabilize iron (II) on storage and in gastrointestinal tract. Components of Ferosol-2 were identified using colour, precipitation- and extraction tests, as well as paper chromatography and absorption spectroscopy. Quantitative analysis of microelements and ascorbic acid was performed using absorption spectroscopy, extraction photometry and iodometric titration methods. Ferosol-2 proved to be more stable than Ferosol-1. Lichfield and Wilkinson method modificated by Roth was used for detection of acute toxicity of Ferosol-2. A local action was estimated on quine pigs. Iron resorption was on 20 days old piglets. Antianaemic effectiveness of Ferosol-2 was evaluated on newborn piglets watching their weight. Experiments with white mice showed low toxicity of Ferosol-2 (LD50 = 4.3 g/kg, for 1 composition and 4.6 g/kg for 2 composition). It does not irritate mucosa of duodenum and ventriculus. Iron in Ferosol-2 was found to be well assimilated in gastrointestinal tract of piglets, easily gets into blood and joins albumen of plasma. After administration of Ferosol-2 to piglets increased iron concentration in blood serum was observed for 3 hours (1 composition) and 6 hours (2 composition). Experimental data showed increased resorption of iron in Ferosol-2, 2 composition due to ascorbic acid. Components of Ferosol-2 are well assimilated and join erythropoetic processes. Ferosol-2 leads to quicker weight gain as well as significantly higher amount of hemoglobin and red blood cells in piglets.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Administration, Oral
  • Anemia, Iron-Deficiency / blood
  • Anemia, Iron-Deficiency / drug therapy*
  • Anemia, Iron-Deficiency / metabolism
  • Animals
  • Animals, Newborn
  • Ascorbic Acid / analysis
  • Calcium / analysis
  • Erythrocyte Count
  • Erythropoiesis
  • Ferrous Compounds / administration & dosage
  • Ferrous Compounds / chemistry
  • Ferrous Compounds / therapeutic use*
  • Ferrous Compounds / toxicity
  • Guinea Pigs
  • Hemoglobins
  • Iron / metabolism
  • Manganese / analysis
  • Mice
  • Oxalates / administration & dosage
  • Oxalates / therapeutic use
  • Photometry
  • Powders
  • Spectrophotometry
  • Spectrum Analysis
  • Swine
  • Time Factors

Substances

  • Ferrous Compounds
  • Hemoglobins
  • Oxalates
  • Powders
  • Manganese
  • Iron
  • Ascorbic Acid
  • Calcium