[Morphogenesis of thoracic aorta aneurysms: investigation of matrix metalloproteinases and their tissue inhibitors]

Medicina (Kaunas). 2002;38(1):31-5.
[Article in Lithuanian]

Abstract

The matrix metalloproteinases are a large group of proteases with a central role of the degradation of all types of extracellular matrix. The present study investigated expression of matrix metalloproteinases (MMP-1, -2, -9) and their inhibitors (TIMP-1, -2) in chronic Aneurysm of the Thoracic Aorta (ATA) and Post-Stenotic Dilatation of the ascending aorta due to valvular aortic stenosis (PSD). Fragments of the ascending aorta that had been taken from the patients during coronary by-pass surgery were used as controls. Immunohistochemical investigation showed that medical SMC in the samples taken from aortas with ATA and PDS expressed a stronger immunoreactivity for MMP-1, -2, -9 and TIMP-1, -2 as compared to controls. It can be suggested that during formation of ATA and PSD, production of MMPs and TIMPS by medial smooth muscle cells is of great importance.

Publication types

  • Comparative Study
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aorta, Thoracic / metabolism
  • Aorta, Thoracic / pathology
  • Aortic Aneurysm, Thoracic / enzymology*
  • Aortic Aneurysm, Thoracic / pathology
  • Aortic Valve Stenosis / etiology
  • Aortic Valve Stenosis / metabolism*
  • Aortic Valve Stenosis / pathology
  • Calcinosis / metabolism
  • Calcinosis / pathology
  • Data Interpretation, Statistical
  • Dilatation, Pathologic
  • Female
  • Histocytochemistry
  • Histological Techniques
  • Humans
  • Male
  • Matrix Metalloproteinases / metabolism*
  • Middle Aged
  • Morphogenesis
  • Sex Factors
  • Tissue Inhibitor of Metalloproteinases / metabolism*
  • Tunica Media / enzymology
  • Tunica Media / metabolism
  • Tunica Media / pathology

Substances

  • Tissue Inhibitor of Metalloproteinases
  • Matrix Metalloproteinases