Histone mRNA expression: multiple levels of cell cycle regulation and important developmental consequences

Curr Opin Cell Biol. 2002 Dec;14(6):692-9. doi: 10.1016/s0955-0674(02)00387-3.

Abstract

Histone mRNA metabolism is tightly coupled to cell cycle progression and to rates of DNA synthesis. The recent identification of several novel proteins involved in histone gene transcription and pre-mRNA processing has shed light on the variety of mechanisms cells employ to achieve this coupling.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Cell Cycle
  • Gene Expression Regulation*
  • Gene Expression Regulation, Developmental
  • Histones / biosynthesis
  • Histones / genetics*
  • Models, Genetic
  • Oogenesis
  • RNA Precursors / metabolism
  • RNA Processing, Post-Transcriptional
  • RNA Stability
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / metabolism*
  • Signal Transduction
  • Transcription, Genetic

Substances

  • Histones
  • RNA Precursors
  • RNA, Messenger