Abstract
The prominent role of pro-inflammatory cytokines produced by T helper-1 (T(H1)) cells in regulating autoimmune responses in vitro and in vivo has been demonstrated. Recent observations of T cell polarisation by regulatory transcription factors--especially T-bet (T-box expressed in T cells)--raise the question of their influence in controlling autoimmune diseases. Here, the authors summarise recent observations of the role of T-bet in controlling chronic inflammatory and autoimmune diseases and discuss the implications of these findings for future therapeutic approaches.
MeSH terms
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Animals
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Autoimmune Diseases / drug therapy*
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Autoimmune Diseases / metabolism
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Celiac Disease / immunology
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Cell Differentiation
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Colitis / immunology
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Crohn Disease / immunology
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Cytokines / biosynthesis
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Cytokines / genetics*
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Cytokines / physiology
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Disease Models, Animal
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Inflammatory Bowel Diseases / immunology
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Interferon-gamma / physiology
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Intestinal Mucosa / immunology
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Intestinal Mucosa / microbiology
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Lupus Erythematosus, Systemic / immunology
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Lymphocyte Activation
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Mice
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Mice, Inbred MRL lpr / immunology
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Mice, Knockout
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Mice, Transgenic
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T-Box Domain Proteins
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Th1 Cells / cytology
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Th1 Cells / immunology*
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Th1 Cells / metabolism
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Th2 Cells / immunology
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Transcription Factors / antagonists & inhibitors*
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Transcription Factors / deficiency
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Transcription Factors / physiology
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Transcription, Genetic / drug effects
Substances
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Cytokines
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T-Box Domain Proteins
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T-box transcription factor TBX21
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Transcription Factors
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Interferon-gamma