PACAP activated adenylate cyclase in human sweat glands. An ultracytochemical study

Eur J Histochem. 2002;46(3):223-8. doi: 10.4081/1683.

Abstract

The ultracytochemical localization of adenylate cyclase (AC) was studied after stimulation with pituitary adenylate cyclase activating peptide (PACAP) in human sweat glands. PACAP stimulated AC in both eccrine and apocrine glands. In the secretory cells, enzymatic activity was associated with membranes involved in the secretory mechanism. In both glands, the cells of the excretory duct and myoepithelial cells presented AC activity. These localizations of enzymatic activity suggest a role for PACAP in regulating glandular secretion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenylyl Cyclases / metabolism*
  • Adult
  • Apocrine Glands / drug effects
  • Apocrine Glands / enzymology
  • Apocrine Glands / ultrastructure
  • Eccrine Glands / drug effects
  • Eccrine Glands / enzymology
  • Eccrine Glands / ultrastructure
  • Enzyme Activation / drug effects
  • Female
  • Histocytochemistry
  • Humans
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Neuropeptides / pharmacology*
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Sweat Glands / drug effects
  • Sweat Glands / enzymology*
  • Sweat Glands / ultrastructure

Substances

  • ADCYAP1 protein, human
  • Neuropeptides
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Adenylyl Cyclases