Abstract
In the present study, we examined the effects of repeated ischemia (10 min x 2, 1 hr interval) on spatial memory in rats in an 8-arm radial maze test compared with single ischemia (10 min x 1). Repeated ischemia produced more severe impairment of spatial memory and stronger TUNEL-positive immunoreactivity in the hippocampal CA1 region than single ischemia at 7 days after reperfusion. Moreover, repeated ischemia altered bcl-family expression, which is related to apoptosis, while this was not affected by single ischemia. These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / physiology
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Animals
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Cell Death
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Genes, bcl-1 / physiology*
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Hippocampus / pathology
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Hypoxia-Ischemia, Brain / genetics*
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Hypoxia-Ischemia, Brain / pathology
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Hypoxia-Ischemia, Brain / psychology*
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In Situ Nick-End Labeling
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Male
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Maze Learning / physiology
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Memory Disorders / genetics*
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Memory Disorders / pathology
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Memory Disorders / psychology*
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Neurotransmitter Agents / physiology
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Norepinephrine / physiology
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Rats
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Rats, Wistar
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Reperfusion Injury / genetics*
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Reperfusion Injury / pathology
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Reperfusion Injury / psychology*
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Reverse Transcriptase Polymerase Chain Reaction
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Space Perception / physiology*
Substances
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Neurotransmitter Agents
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Acetylcholine
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Norepinephrine