Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process

Org Lett. 2002 Dec 12;4(25):4435-8. doi: 10.1021/ol026981x.

Abstract

[reaction: see text] The stable, crystalline Cr(III)/sulfonamide complex 1a is shown to be an effective catalyst for the Ni/Cr-mediated coupling reaction. A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupling reactions. With this catalyst, a concise and efficient synthesis of the C14-C26 segment of halichondrins has been developed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Catalysis
  • Chromium / chemistry*
  • Ethers, Cyclic / chemical synthesis*
  • Ethers, Cyclic / chemistry*
  • Molecular Conformation
  • Molecular Structure
  • Nickel / chemistry*
  • Stereoisomerism

Substances

  • Ethers, Cyclic
  • Chromium
  • Nickel