Abstract
We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports.
Copyright 2002 Movement Disorder Society
MeSH terms
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Aged
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Antiparkinson Agents / adverse effects*
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Antiparkinson Agents / therapeutic use
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Catechol O-Methyltransferase Inhibitors
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Catechols / adverse effects*
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Catechols / therapeutic use
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Chemical and Drug Induced Liver Injury / diagnosis
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Chemical and Drug Induced Liver Injury / etiology*
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Drug Interactions
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Drug Therapy, Combination
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Female
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Humans
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Liver Function Tests*
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Nitriles
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Parkinson Disease / drug therapy*
Substances
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Antiparkinson Agents
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Catechol O-Methyltransferase Inhibitors
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Catechols
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Nitriles
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entacapone