Entacapone-induced hepatotoxicity and hepatic dysfunction

Mov Disord. 2002 Nov;17(6):1362-5; discussion 1397-1400. doi: 10.1002/mds.10342.

Abstract

We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiparkinson Agents / adverse effects*
  • Antiparkinson Agents / therapeutic use
  • Catechol O-Methyltransferase Inhibitors
  • Catechols / adverse effects*
  • Catechols / therapeutic use
  • Chemical and Drug Induced Liver Injury / diagnosis
  • Chemical and Drug Induced Liver Injury / etiology*
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • Humans
  • Liver Function Tests*
  • Nitriles
  • Parkinson Disease / drug therapy*

Substances

  • Antiparkinson Agents
  • Catechol O-Methyltransferase Inhibitors
  • Catechols
  • Nitriles
  • entacapone