The cytotoxic and antitumor activities of the imidazole alkaloid polycarpin from the ascidian Polycarpa aurata and its synthetic analogues

Dokl Biochem Biophys. 2002 Jul-Aug:385:213-8. doi: 10.1023/a:1019915507568.
No abstract available

MeSH terms

  • Alkaloids / pharmacology*
  • Alkaloids / toxicity*
  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / toxicity
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Imidazoles / pharmacology*
  • Imidazoles / toxicity*
  • Melanoma, Experimental / drug therapy
  • Mice
  • Mice, Inbred C57BL
  • Models, Chemical
  • Neoplasms / drug therapy*
  • Spleen / cytology
  • Time Factors
  • Urochordata

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Imidazoles
  • polycarpine