The TB structural genomics consortium: providing a structural foundation for drug discovery

Curr Drug Targets Infect Disord. 2002 Jun;2(2):121-41. doi: 10.2174/1568005023342551.

Abstract

Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acyltransferases*
  • Aldehyde-Lyases / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antigens, Bacterial*
  • Bacterial Proteins / chemistry*
  • Cytochrome P-450 Enzyme System / chemistry
  • Drug Design*
  • Genomics*
  • Glutamate-Ammonia Ligase / chemistry
  • Methyltransferases / chemistry
  • Mycobacterium tuberculosis / chemistry*
  • Mycobacterium tuberculosis / drug effects*
  • Myo-Inositol-1-Phosphate Synthase / chemistry
  • Oxidoreductases / chemistry
  • Protein Disulfide-Isomerases / chemistry

Substances

  • Anti-Bacterial Agents
  • Antigens, Bacterial
  • Bacterial Proteins
  • Cytochrome P-450 Enzyme System
  • Oxidoreductases
  • InhA protein, Mycobacterium
  • Methyltransferases
  • cyclopropane synthetase
  • Acyltransferases
  • antigen 85B, Mycobacterium tuberculosis
  • Aldehyde-Lyases
  • dihydroneopterin aldolase
  • Protein Disulfide-Isomerases
  • Myo-Inositol-1-Phosphate Synthase
  • Glutamate-Ammonia Ligase

Associated data

  • PDB/1FOP
  • PDB/1KP9
  • PDB/1KPG
  • PDB/1KPH
  • PDB/1KPI
  • PDB/1L1E