Several peroxidase isozymes have been described in Drosophila melanogaster. We describe a peroxinectin-like gene (Dpxt) in D. melanogaster. Peroxinectin is a cell-adhesive hemoperoxidase which binds superoxide dismutase and mediates blood cells attachment and spreading in the crayfish Pacifastacus leniusculus. The Dpxt predicted protein has a putative RGD-integrin binding tripeptide. The Dpxt mRNA is present in high amounts in late oogenesis and in early embryogenesis until the cellular blastoderm stage. It is virtually absent at other stages of the Drosophila life cycle, suggesting that Dpxt function is restricted to the early stages of fly development.