Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats

S E Zhuikova; V I Sergeev; G E Samonina; N F Myasoedov

doi:10.1023/a:1020285909696

Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats

Bull Exp Biol Med. 2002 Jun;133(6):577-9. doi: 10.1023/a:1020285909696.

Authors

S E Zhuikova¹, V I Sergeev, G E Samonina, N F Myasoedov

Affiliation

¹ Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.

PMID: 12447470
DOI: 10.1023/a:1020285909696

Abstract

Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented reduction of blood flow induced by indomethacin. The antiulcer effect of Semax is probably related to improvement of blood flow in the gastric wall disturbed by indomethacin.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adrenocorticotropic Hormone / analogs & derivatives*
Adrenocorticotropic Hormone / pharmacology*
Animals
Anti-Ulcer Agents / pharmacology*
Indomethacin / adverse effects*
Male
Peptide Fragments / pharmacology*
Rats
Regional Blood Flow / drug effects
Stomach / blood supply*
Stomach / drug effects
Stomach Ulcer / chemically induced
Stomach Ulcer / drug therapy
Stomach Ulcer / physiopathology*

Substances

Anti-Ulcer Agents
Peptide Fragments
ACTH (4-7), Pro-Gly-Pro-
Adrenocorticotropic Hormone
Indomethacin