New onoceranoid triterpene constituents from Lansium domesticum

Tadamitsu Tanaka; Masami Ishibashi; Haruhiro Fujimoto; Emi Okuyama; Takashi Koyano; Thaworn Kowithayakorn; Masahiko Hayashi; Kanki Komiyama

doi:10.1021/np020239o

New onoceranoid triterpene constituents from Lansium domesticum

J Nat Prod. 2002 Nov;65(11):1709-11. doi: 10.1021/np020239o.

Authors

Tadamitsu Tanaka¹, Masami Ishibashi, Haruhiro Fujimoto, Emi Okuyama, Takashi Koyano, Thaworn Kowithayakorn, Masahiko Hayashi, Kanki Komiyama

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

PMID: 12444710
DOI: 10.1021/np020239o

Abstract

Three new natural onoceranoid triterpenes, lansionic acid (1), 3beta-hydroxyonocera-8(26),14-dien-21-one (2), and 21alpha-hydroxyonocera-8(26),14-dien-3-one (3), were isolated from the fruit peel of Lansium domesticum together with two known triterpenoids (4 and 5), and their structures were elucidated from spectral data. These triterpenoids exhibited mild toxicity against brine shrimp (Artemia salina).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Artemia / drug effects
Fruit / chemistry
Meliaceae / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Spectrophotometry, Infrared
Thailand
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

21alpha-hydroxyonocera-8(26),14-dien-3-one
3beta-hydroxyonocera-8(26),14-dien-21-one
Triterpenes
lansionic acid