Abstract
Three new acylated triterpene saponins 1-3, with a quillaic acid as aglycon, were isolated from the roots of Silene fortunei together with a known phytoecdysteroid (20-hydroxyecdysone). The compounds were characterized mainly by a combination of 2D NMR techniques, mass spectrometry, and chemical methods. Saponins 1-3, jenisseensosides C and D (4, 5), and 6 (deacylated form of 2/3 and 4/5) were found to stimulate the proliferation of the Jurkat tumor cell lines at low concentration. At high concentration, 2/3 and 4/5 inhibited the proliferation of the cells and suggested the induction of apoptosis.
MeSH terms
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Acetylation
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Apoptosis / physiology
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Humans
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Hydrolysis
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Jurkat Cells / drug effects
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Lymphocyte Activation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Silene / chemistry*
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Stereoisomerism
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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3-O-(galactopyranosyl-(1-2)-glucuronopyrnosyl)quillaic acid-28-O-(arabinopyranosyl)-(1-2)-arabinopyranosyl-(1-3)-xylopyranosyl-(1-4)-rhamnopyranosyl-(1-2))-(6-O-acetylglucopyranosyl-(1-3)-4-O-acetylfucopyranoside
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3-O-(galactopyranosyl-(1-2)-glucuronopyrnosyl)quillaic acid-28-O-rhamnopyranosyl-(1-2)-3-O-acetyl-4-p-methoxycinnamoyl fucopyranoside
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Saponins
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Triterpenes
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jenisseensoside C
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jenisseensoside D