Synthesis of (+)-Lasonolide A: (-)-lasonolide A is the biologically active enantiomer

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3519-20. doi: 10.1016/s0960-894x(02)00821-1.

Abstract

(+)-Lasonolide A was synthesized following the established procedure. (-)-Lasonolide A was found to be the biologically active enantiomer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Cell Division / drug effects
  • Humans
  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Macrolides / pharmacology*
  • Optical Rotation
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Macrolides
  • lasonolide A