Abstract
[reaction: see text] The total synthesis of alstonisine was accomplished in enantiospecific fashion in an overall yield of 12% (from tryptophan methyl ester) in 17 reaction vessels. The structure of alstonisine (1) has been determined by NOE spectroscopic experiments and was confirmed by single-crystal X-ray analysis.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry*
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Alstonia / chemistry
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Indoles / chemical synthesis*
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Indoles / chemistry*
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Molecular Conformation
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Molecular Structure
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Oxindoles
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Spiro Compounds
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Stereoisomerism
Substances
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Alkaloids
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Indoles
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Oxindoles
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Spiro Compounds
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alstonisine