Abstract
[reaction: see text] The relative and absolute configuration of the pneumocandin B(0) side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / chemistry*
-
Antifungal Agents / chemical synthesis*
-
Antifungal Agents / chemistry*
-
Echinocandins
-
Magnetic Resonance Spectroscopy
-
Molecular Conformation
-
Molecular Structure
-
Peptides*
-
Peptides, Cyclic / chemical synthesis*
-
Peptides, Cyclic / chemistry*
Substances
-
Anti-Bacterial Agents
-
Antifungal Agents
-
Echinocandins
-
Peptides
-
Peptides, Cyclic
-
pneumocandin B(0)