Synthesis of potential anti-HIV GP120 inhibitors using a lysine template

J Enzyme Inhib Med Chem. 2002 Jun;17(3):175-82. doi: 10.1080/1475636021000003174.

Abstract

Various acylated proteins have been reported in the literature to possess anti-HIV activity. Described here is the preparation of lysine monomers, dimers and trimers acylated with various anhydrides and dioxalanones as simplified mimics of the acylated proteins. Compounds were assayed against HIV-infected C8166 cells and some showed weak anti-HIV activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Anti-HIV Agents / chemical synthesis*
  • HIV Envelope Protein gp120 / chemistry*
  • HIV-1 / drug effects
  • Lysine / chemistry*
  • Lysine / pharmacology
  • Oligopeptides / chemical synthesis
  • Oligopeptides / pharmacology
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • HIV Envelope Protein gp120
  • Oligopeptides
  • Lysine