Alkaloids from the roots of Senecio macedonicus Griseb

Veselin Christov; Bozhanka Mikhova; Radostina Alexandrova; Daniela Dimitrova; Elena Nikolova; Liuba Evstatieva

doi:10.1515/znc-2002-9-1004

Alkaloids from the roots of Senecio macedonicus Griseb

Z Naturforsch C J Biosci. 2002 Sep-Oct;57(9-10):780-4. doi: 10.1515/znc-2002-9-1004.

Authors

Veselin Christov¹, Bozhanka Mikhova, Radostina Alexandrova, Daniela Dimitrova, Elena Nikolova, Liuba Evstatieva

Affiliation

¹ Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia. christov@orgchm.bas.bg

PMID: 12440711
DOI: 10.1515/znc-2002-9-1004

Abstract

The new alkaloids 7-,9-diangeloylplatynecine (1) and 8-episarracine N-oxide (2), were isolated and identified from the roots of Senecio macedonicus. Another one, 8-epineosarracine was detected by GC/MS analyses of the crude alkaloid mixture. The cytotoxicity and biological activity of the alkaloids were tested on normal murine spleen lymphocytes and P3U1 mouse myeloma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Division / drug effects
Gas Chromatography-Mass Spectrometry
Lymphocytes / drug effects
Lymphocytes / immunology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Models, Molecular
Molecular Conformation
Plant Roots / chemistry*
Pyrrolizidine Alkaloids / chemistry*
Pyrrolizidine Alkaloids / isolation & purification
Pyrrolizidine Alkaloids / pharmacology
Spectrometry, Mass, Electrospray Ionization
Spleen / immunology

Substances

Pyrrolizidine Alkaloids
sarracine