Abstract
Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection. The double-mutant contains no foreign DNA, is highly attenuated, protects pigs from homologous challenge upon a single aerosol application, and facilitates the serological discrimination of immunized and infected herds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinobacillus Infections / microbiology
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Actinobacillus Infections / prevention & control
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Actinobacillus Infections / veterinary*
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Actinobacillus pleuropneumoniae / classification
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Actinobacillus pleuropneumoniae / genetics
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Actinobacillus pleuropneumoniae / immunology*
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Actinobacillus pleuropneumoniae / pathogenicity
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Animals
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Antibodies, Bacterial / blood
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Bacterial Proteins / genetics
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Bacterial Vaccines / genetics
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Bacterial Vaccines / immunology*
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Gene Deletion*
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Hemolysin Proteins
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Immunization
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Serotyping
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Swine
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Swine Diseases / microbiology
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Swine Diseases / prevention & control*
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Vaccines, Attenuated / genetics
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Vaccines, Attenuated / immunology*
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Virulence
Substances
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Antibodies, Bacterial
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ApxII toxin, bacteria
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Bacterial Proteins
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Bacterial Vaccines
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Hemolysin Proteins
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Vaccines, Attenuated