Evidence for constitutive expression of bovine adrenal a3beta4* nicotinic acetylcholine receptors

Ann N Y Acad Sci. 2002 Oct:971:145-7. doi: 10.1111/j.1749-6632.2002.tb04450.x.

Abstract

Many pathological conditions involve alterations in expression of nicotinic acetylcholine receptors (nAChRs). The following studies were designed to investigate cellular mechanisms involved with expression and turnover of alpha3beta4* nAChRs. These studies support constitutive turnover of adrenal alpha3beta4* nAChRs and the use of cultured adrenal chromaffin cells to study nAChR regulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Chromaffin Cells / metabolism*
  • Down-Regulation
  • Gene Expression Regulation*
  • Puromycin / pharmacology
  • Receptors, Nicotinic / biosynthesis*
  • Receptors, Nicotinic / genetics*
  • Time Factors

Substances

  • Receptors, Nicotinic
  • nicotinic receptor alpha3beta4
  • Puromycin