The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site

Peter M Colman; Brian J Smith

doi:10.1016/s0969-2126(02)00888-2

The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site

Structure. 2002 Nov;10(11):1466-8. doi: 10.1016/s0969-2126(02)00888-2.

Authors

Peter M Colman¹, Brian J Smith

Affiliation

¹ Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia.

PMID: 12429084
DOI: 10.1016/s0969-2126(02)00888-2

Abstract

The structure of the trypanosomal trans-sialidase reveals a canonical sialidase catalytic site elaborated with a conformational switch that creates an adjacent binding pocket for lactose.

MeSH terms

Animals
Catalysis
Catalytic Domain
Glycoproteins
Lactose / chemistry
Ligands
Neuraminidase / chemistry*
Peptides / chemistry
Protein Binding
Protein Conformation
Trypanosoma cruzi / enzymology*

Substances

Glycoproteins
Ligands
Peptides
trans-sialidase
Neuraminidase
Lactose